Real Madrid 3-0 Leganes
Real Madrid are on the edge of qualifying for the quarter-finals after cruising to a 3-0 win over Leganes at the Santiago Bernabeu.
Sergio Ramos, Lucas Vazquez and Vinicius Junior were all on target for the home side, who have one foot in the next round.
Girona 1-1 Atletico Madrid
Atletico Madrid will take a slight advantage in the second leg after drawing 1-1 at the Estadi Municipal de Montilivi.
Antoine Griezmann opened the scoring for the visitors after nine minutes, before Anthony Lozano restored parity in the 34th minute.
Getafe 1-0 Real Valladolid
Angel's solitary strike in the 92nd minute guided Getafe to a narrow first-leg victory at the Coliseum Alfonso Pérez.
Villarreal 2-2 Espanyol
Villarreal rallied back from two goals down to secure a 2-2 draw on Wednesday evening.
Sergi Darder and Alejandro López handed the visitors a two-goal lead with strikes in the 15th and 71st minute respectively.
The Yellow Submarine hit back through Karl Toko Ekambi in the 85th minute before Carlos Bacca levelled matters four minutes later.