Kaizer Chiefs are set to face Mamelodi Sundowns, Simba SC or Esperance de Tunis in the quarter-finals of the Total CAF Champions League.
Chiefs secured qualification for the last-eight of the competition on Saturday evening via away goals in the head to head rulings against Horoya AC following their 2-2 draw away from home.
Goals from Daniel Cardoso from the spot and Khama Billiat late into the second-half was enough for the Soweto giants to oust the 2018/19 quarter-finalists who were favourites in the tie on the night.
With the Guinea Ligue 1 Pro giants 22 games unbeaten in the competition at home, the result from Gavin Hunt's side is a historic feat achieved against the odds as they advanced from Group C with Wydad Casablanca.
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Amakhosi will now avoid the two-time Champions League winners in the quarter-finals and will now be scheduled to face either Sundowns, Simba or Esperance when the draw takes place this month.
It marks the first time in South African football history that two club's advance to the knockout stage of the competition with Masandawana winning Group B despite their surprise 2-0 defeat to CR Belouizdad on Friday.
The official draw for Africa's elite club competition will take place on 30 April at the CAF headquarters in Cairo, Egypt.