The ‘Wild Dogs’ are looking to build on their showing at the 2017 African Nations Cup finals in Gabon, where they took a single point from their three first round matches.
Cande, 69, is coaching Guinea Bissau for the second time, having previously led the team from 2003 to 2010.
"We'll gain experience from this game," said Cande through a translator. "For them [the Guinea Bissau players] it'll be good to test themselves and learn.
"It'll also be a privilege to go against a big team where there's great players. If you look at the South African league, it is like something in Europe. For me this is a good experience."
But Cande admits to knowing little about this current Bafana set-up.
"When it comes to Bafana I have not got much idea about the team, but I know about South African football ... I'm talking about a player like Benni McCarthy and others who have played in Europe," he reveals.
"I know that the country produces good players, but when you talk about the Bafana Bafana of now as a team, I have no clue.
"But I'll also bring something new as we have a new team in our country. I believe that from this game, they'll gain something better for the national team."