Myeni has impressed at training since missing last weekend's MTN8 Final defeat to Platinum Stars with a groin strain.
"He is a brilliant player. I need a guy like him to carry the team," De Sa told his club's official website.
"He is showing at training that he wants to play so let us see how it goes till Friday. He did well in the few sessions we have had.
"Against Esperance we will need a player like him to keep those guys on the back foot so, Sifiso should be fine to play on Saturday," concluded the former Bidvest Wits mentor.
Pirates will host Esperance in the first leg of their semi-final duel at Orlando Stadium, with the game now starting at 18.00, an hour earlier than originally advertised.