Sundown start the defence of their title with a clash against the Soweto giants at the Lucas Moripe Stadium on Saturday, 4 August.
Orlando Pirates will also be in action on the same day as they host Highlands Park in the late kick-off at Orlando Stadium.
A statement from the PSL read, 'The Premier Soccer League has released the 2018/19 Absa Premiership fixtures this afternoon.
'The opening match of the #AbsaPrem will be on Saturday, 04 August 2018 featuring defending Absa Premiership champions, Mamelodi Sundowns against Kaizer Chiefs at Loftus Stadium.
'Kick-off is at 15h00.
'On the same day, former champions Bidvest Wits will be at home against Free State Stars at 18h00. SuperSport United will travel to Cape Town to play Cape Town City also at 18h00.
'Later (20h15), Absa Premiership newly promoted side, Highlands Park will play Orlando Pirates at the Orlando Stadium. At the same time, Amazulu will be hosting Baroka FC at King Zwelithini Stadium.
'On Sunday, Maritzburg United will be up against Lamontville Golden Arrows in the KwaZulu Natal derby at Harry Gwala Stadium while Bloemfontein Celtic will play Chippa United at Dr Molemela Stadium. Kick-off for both matches is 15h00.
'The League has also confirmed that the last fixture of the Absa Premiership will be played on 11 May 2019.
'The Nedbank Cup final will be played a week later, 18 May 2019.'