Vilakazi ruptured his left Achilles tendon while in the Bafana Bafana camp, during a friendly match against SuperSport United at Megawatt Park in Johannesburg last Tuesday.
Vilakazi was withdrawn from the squad and Cape Town City winger Gift Links was called up ahead of the 2019 Africa Cup of Nations qualifiers against Seychelles.
"I am not sure, but it looks like it's the rest of the season. He's got an Achilles tendon injury, so that's a blow," says Sundowns spokesperson Thulani Thuswa.
Vilakazi has been one of coach Pitso Mosimane's key men in the side, featuring in seven of Sundowns' matches in all competitions. He has two goals and one assist.
Mosimane, though, has a number of players in his squad to call on in the absence of Vilakazi. The likes of Gaston Sirino, Themba Zwane, Phakamani Mahlambi and Lebohang Maboe are all there to get the job done for Sundowns.
Vilakazi will miss out on the CAF Champions League and probably the 2019 Africa Cup of Nations, which is a big blow for him.
The former Bidvest Wits captain has received a lot of support from friends, family and supporters since sustaining the knock. This is not the first time in his career he has sustained a long-term injury.