The Citizens progressed to the last eight of the competition with a comfortable 3-1 aggregate win over Dynamo Kiev in the Round of 16, and De Bruyne, who marked his return from injury with a well-taken goal against Bournemouth on the weekend, feels the English outfit are definitely in with a chance.
"It's a tournament, so you never know,” the Belgian said. “If the team plays at its best then we always have a chance.
"If you want to win it then you have to win against the big teams also."
City have been paired against French champions Paris Saint-Germain, who have lost just once at home in their last 25 matches, yet De Bryune is quietly confident of a positive result ahead of the first leg in Paris on Wednesday evening.
"Everyone maybe has a different view because if you get a 0-0 over there it can also be good," he said.
"I think our team always creates chances, I think we are not a defensive team, so I don't think that’s the main issue. We'll see what happens."