Messi has starred for La Albiceleste in Brazil, winning four straight man-of-the-match awards to go with his four goals at the showpiece.
Hazard, while full of respect for Messi and his teammates, is nevertheless relishing the chance to make history with his country, whose previous best showing at the event was a fourth-placed finish in 1986.
"I think that we are two good teams," Hazard told reporters in Salvador after his side's 2-1 win over United States in the last-16.
"I don't know how it will go but, for me, it's 50-50. They have Messi, [Gonzalo] Higuain and [Ezequiel] Lavezzi. But we have a lot of great defenders.
"We know that the best player in the world is in their team. [Their overall form] is good, but they have one very big player and he makes the difference in every game. If we can stop Messi, it'll be easier.
"I don't know how we can stop him. We won't be afraid, though.
"We'll watch some videos and just try to win because it's a big game for this generation of players. It's maybe the biggest game of my life.
"And I hope to continue this World Cup. We can make history."