The Buccaneers will be looking to open a three-point gap between themselves and second-placed Mamelodi Sundowns while Lidoda Duvha are just a point above the relegation zone.
"Every game is big, every game's got a different meaning," Kerr tells KickOff.com.
"In terms of attitude I'm looking for a response from the defeat [at Polokwane City] on Sunday, because that was kind of hard to accept. We are ready to go up against Pirates and we know it's gonna be tough. We've got to be professional, we got to be disciplined. We've got to make sure that when we have the ball we keep it better, we use it better especially in the final third.
"I think we will get chances because Orlando Pirates are desperate for the league. It's gonna be tough, it's gonna be a battle. Pirates are on top of the league and if they get another three points they move three points above Sundowns, which is what they'll be aiming for.
"We've got to concentrate on what we do when we have the ball. We don't need to give it away as much as we did on Sunday, especially in good positions. Don't play with fear, play with our usual enjoyment and enthusiasm. Be disciplined and very respectful to the league leaders."
The Limpopo side will be without influential player Phathusedzo Nange, who is not part of the squad because of a hamstring injury. He is expected to be back after three days.