Amakhosi will be without two defenders, while The Citizens will miss their head coach for their crunch clashes against Bidvest Wits and Mamelodi Sundowns respectively.
Chiefs will have to make do without centre-back Teenage Hadebe, as well as utility fullback Joseph Molangoane, who will complete a two-match ban, when they turn out at the Bidvest Stadium on Saturday.
City play host to The Brazilians at the Athlone Stadium on Friday evening, with Benni McCarthy serving the last of his two-match ban after being sent off in the iKapa derby against Ajax Cape Town.
Meanwhile, Bakgaga right-back Matome Kgoetyane will be absent when they tackle Ea Lla Koto, who have centre-back Bangaly Keita ruled out, on Saturday afternoon.
The Chilli Boys' star signing in the January transfer window Linda Mntambo, who has picked up three man-of-the-match awards in four games, will miss out when his side faces Platinum Stars on Sunday afternoon.