Royal Eagles hitman George has bagged 19 goals this season - three more than Cele.
The two clubs will meet at Harry Gwala Stadium on Saturday as log leaders Thanda look to extend their nine-point lead over closet rivals Black Leopards with six matches left.
"We don't have a special plan for him [George]," says Sikhakhane. "If you have noticed he scores mostly penalties and maybe he's scored eight penalties compared to Mhlengi.
"Mhlengi scores in open play and you can't compare him with George. I know he [George] is going to be there around the 18 yards.
"If you can calculate his goals he scored, most of them are the spot kicks. But we are talking about strikers that can score in the open game and we are not worried about him unless he can get a penalty, then he'll score."
Meanwhile, Sikhakhane says Eagles are more unpredictable than Leopards, who they drew 1-1 with in midweek.
Big spenders Eagles were challenging Thanda at the top for the majority of the season but they've fallen to the wayside, and they welcome Sikhakhane's side having shockingly lost 3-1 to AmaZulu on Wednesday.
A win for Thanda tomorrow against Kosta Papic's side will see them only need seven more points to confirm their return to the PSL for the first time since 2009.
"It'll be a tough one but it's going to be a different game compared to the game against Black Leopards.
"We are going to put them under pressure. We have got nothing to lose there and we are going to play football.
"If you play against Eagles, Eagles is not predictable; they can win today, they can lose tomorrow and sometimes they win but you don't know how they won.
"But for us it is to prepare ourselves and go and get the points there."