Tottenham manager Villas-Boas worked for seven years as a scout for Mourinho at Porto, Chelsea and Inter Milan.
However, they reportedly fell out at Milan, with Villas-Boas going on to coach FC Porto, the Blues and now Spurs.
Villas-Boas, who said his managerial ambitions were not being met in the Italian capital, admitted he used to have a "great and professional relationship" with Mourinho but this is no longer the case.
Mourinho, when asked for a response, said: "I don't describe (the relationship), because I'm not a kid to discuss relationships with the media. It's a personal thing.
"I don't care what he says. I'm here, not to comment on what he says or what to know what he says. I'm not interested."
When pressed on the matter, he added: "It's enough from me.
"I have nothing to say, nothing at all.
"I'm not discussing here in front of you. For me there is no point.
"I'm not disappointed. I'm just here to speak about anything you want related to the game, not related to this situation."