Kick-off is at 8.15pm.
Chiefs continued their excellent start to the season on Monday night when they defeated Bidvest Wits 3-1 away from home.
The Soweto giants will be looking to retain their 100 percent home record, having defeated Mamelodi Sundowns and Black Leopards in their two previous home matches, but they face a confident Chippa United, who won their first Premiership match this week.
Chippa claimed their first top-flight win on Wednesday night when they defeated Bloemfontein Celtic 2-1 at home.
The Cape Town side lost 1-0 to Mamelodi Sundowns and drew 0-0 with Black Leopards in their two previous away games.
The Chilli Boys are 10th on the Premiership log with five points from as many matches. This will be their first League meeting with Kaizer Chiefs, and they will be looking to make an impression.
Chiefs' line-up from their 3-1 win over Wits: Khune, Gaxa (Zvasiya 65), Mathoho, Mashamaite, Jambo, Lebese (Masango 72), Katsande, Letsholonyane, Tshabalala, Parker, Nkhatha (Majoro 81)
Chippa's line-up from their 2-1 win over Celtic: Kassally, Khubeka, Sithole, Mvalo, Matomane, Mnguni, Mbenyane (Twala 85), Alexander (Sali 73), Qalanto, Ngebo (Rhode 82), Brown