The England star missed a 1-1 draw with Shakhtar Donetsk in the Champions League on Wednesday after damaging his shin in a training ground clash with teammate Danny Welbeck.
However, Red Devils manager David Moyes thinks Rooney will recover by the weekend.
"My plan wasn’t to use Wayne Rooney," Moyes told reporters after the midweek stalemate.
"He picked up a crack on the shin and its swollen up. He was going to be on the bench but he has not been able to make it.
"I think he will be okay for Saturday. We could have risked him but we decided not to."
Regarding their latest result, Moyes feels his men showed resolve on the road.
"We had to be harder to play against than we have in recent games and we were," he said.
"I’m beginning to understand the players a bit better. They were aware of how tough a game it was going to be and I thought we defended very well.
"There’s a bit of disappointment that we didn’t see the game out but I felt Shakhtar deserved something from the game."