Sundowns suffered their second league defeat of the season when they were beaten 2-1 by Cape Town City on Tuesday night.
The Brazilians have now returned to Gauteng to prepare for an important clash against the Nigerian club. A win could send Sundowns to the Champions league quarter-finals.
"It's wafa wafa that one. It's bigger than this [against Cape Town City]," said Mosimane.
"This one [against Cape Town City] it's okay, it disturbs, you know what I am trying to say. We still have eight games to go. We're going there. No one is going to win eight games in a row against everybody competing with us.
"I think Cape Town City might win the league also. They also put themselves into the pool. I wish them all the luck.
"But we have a big one [against Lobi Stars]. It's national agenda that one. It's to put a star on top of the badge," he added.
After their game against Lobi Stars, they will fly out of the country next week to Morocco to face Wydad Casablanca, whom they beat 2-1 during the first-leg match at home.