Ibrahimovic netted his 17th goal of the Major League Soccer campaign with an outrages volley against reigning champions Toronto FC to bring up the historic milestione.
The 36-year-old now joins Lionel Messi and Cristiano Ronaldo as the only active footballer to reach 500 career goals for club and country.
Ibrahimovic – Sweden's all-time leading scorer with 62 goals in 116 appearances – has enjoyed an illustrious career.
After starting out at Malmo in Sweden, he has gone on to score goals for Ajax, Juventus, Inter, Barcelona, AC Milan, Paris Saint-Germain and United.
Ibrahimovic was PSG's top goalscorer with 156 goals before Edinson Cavani broke his record in January.
Despite losing out 5-3 on the day, the former Juventus striker said he was happy for champions.
"I am happy for Toronto because they will be remembered as my 500th victim," he said after the game.
Cristiano Ronaldo.— LA Galaxy (@LAGalaxy) September 16, 2018
Zlatan Ibrahimović. @Ibra_official joins elite company as the third active player to score 500 career goals across his senior career between club and country. pic.twitter.com/umjiTefx4N