The Congolese must avoid defeat in Blantyre in their last Group 12 match to have any chance of progressing to the last phase of the African qualifiers for the 2010 World Cup finals in South Africa.
The Leopards are due to stay in Johannesburg from October 5-9 before heading to Blantyre for the match on October 11.
DR Congo coach Patrice Neveu has already surprised with an early squad announcement that has seen captain Shabani Nonda axed.
The former Vaal Professionals striker is replaced by Blaise Lelo-Mbele, formerly on the books of Orlando Pirates.
Also in the 20-man squad is the former Ajax Cape Town midfielder Tshinyama Tsholola.
Congo and Malawi both have nine points in Group 12, three behind leaders Egypt. But Congo, with a better goal difference, will make sure of finishing in the top two of the group standings if they avoid defeat against the Malawians.
Malawi warm up for the game against Congo with a match against Bafana Bafana on September 30.