The Blues, who currently top the Premier League standings, will play four matches within the next eight days, including two League encounters, a Champions League tie and a League Cup fixture against Shrewsbury on Tuesday night.
And with the little turnaround time following their 1-1 draw with Manchester United on Sunday, and injuries to star striker Diego Costa, Loic Remy and possible fatigue of Didier Drogba after his two 90-minute appearances last week, Mourinho is anticipating a difficult trip to their League Two opponents.
“I have only one day, we travel to London and we are travelling to Shrewsbury,” the Portuguese tactician said.
“We are in trouble because we have so many injured players. It is even more difficult for us to go. We have to go.
“We now have a difficult match. Because they are doing very well in their league and doing very well against superior teams in the Capital One Cup. It’s a big day for them. We know it will be difficult for us. But that’s football.”
Mourinho hinted at unused forward Andre Schurrle to start against Shrewsbury, as well as a number of other squad players who did not feature against United.
“We are in a difficult situation … but, when you look at the players who didn’t play – Schürrle, Salah, Zouma, Aké, Mikel – these boys are obviously going to have to play,” he said.
Mourinho hopes that Costa, who is still suffering from a hamstring injury as well as a virus he picked up before Sunday’s clash at Old Trafford, will be available again this weekend for the Premier League encounter against QPR.
“I think so,” Mourinho said of Costa’s availability for Saturday. “QPR, one week more, I hope so.
“The virus is fine. It was hard when Costa went to hospital and obviously it doesn’t help to recover from the injury.
“But he didn’t come [to Old Trafford] because of the injury, not because of the virus. He aggravated the hamstring because he played two matches in three days and was not with us.”