The South Americans succumbed to a shock 3-1 defeat to Costa Rica in their opening game, yet Cavani believes his side have the quality to bounce back against the Three Lions in Recife.
"We are difficult to beat," the 27-year-old told The Sun. "We have strong character and personality and if you want to win against us you have to fight.
"We have the tools to react. We have overcome similar situations before. We have to prove we want to overcome this uncomfortable situation.”
Cavani made no excuses for his side’s loss against the Central Americans.
“We have thought about why we lost since the game against Costa Rica," he said.
"It was difficult to accept - not because we thought they were easy, we respected them. But we were playing well and we thought we would start the competition on the right foot.
"We know we lost because we made mistakes. We have seen it, analysed it and we are convinced it was our fault."
The Paris-Saint Germain forward could start tonight’s encounter alongside fit-again Luis Suarez, and is relishing the prospect of linking up with the Liverpool star.
"I've played often with Luis,” Cavani said. “We have achieved wonderful things together.
“We are playing for a national team and all those here are great players.
"In the first match we had Diego Forlan and if Luis plays he will give his best.”
Kick-off for this crucial Group D clash is at 9pm.