The German international had complained about discomfort in his knee during half-time of Arsenal’s last League clash against Chelsea, but continued for the full 90 minutes in his side’s 2-0 loss to the Blues.
Ozil was then called up for international duty, but was promptly sent home after the German medical staff discovered he had suffered ligament damage which could rule out the 26-year-old for the rest of the year.
Club coach Arsene Wenger said he was shocked by the extent of his record signing’s injury, claiming he had not seen any collision during the Chelsea game that could have caused such an injury to his player.
"I am deeply shocked,” the French coach told beIN Sports. “He wasn't involved in a collision with anybody.
"It was just after making a pass with the outside of his foot that he injured his leg so it's very hard to believe that you can damage your ligament with just making a simple pass and it's very difficult to take that he will be out for a while.”
Wenger said Ozil had felt “a crack” in his knee during the game, but left the German on the field as the Gunners were 1-0 down.
"He had a little problem just before he went out at half-time,” Wenger said.
“He had a little pain with his knee, he felt a crack. I said to our physio to keep an eye on him and if there was anything wrong with him, tell me because when you're 1-0 down, you want to keep your offensive players on the pitch."
After receiving widespread criticism that the club is at fault for the long list of injured players at the Emirates, Wenger defended his staff, believing the number of injuries to be “coincidence”.
"I am not a great believer in coincidences, but this time it really is coincidence," he said. "You cannot say our injuries are preparation mistakes. The big injuries we have are really accidental.
"Scientifically we are quite good. We have been hit hard after seven games. I would never have thought we would have had so many bad injuries."
Arsenal currently sit eighth in the Premier League standings and take on eleventh-placed Hull City in their next League encounter on Saturday afternoon.