South Africa will first host the islanders at FNB Stadium on Saturday, October 13, with kick-off scheduled for 15h00 in Johannesburg.
Three days later the nations will revive hostilities at Stade Linite at 16h30 local time (14h30 SA time).
Baxter has called up Lebo Phiri, Thapelo Morena, Lebohang Maboe, Thabo Nodada, Dino Ndlovu and Phakamani Mahlambi, who all missed out on the disappointing goalless draw with Libya at Durban's Moses Mabhida Stadium on September 8.
The Brit has decided against selecting SuperSport United striker Bradley Grobler, Mamelodi Sundowns attacker Themba Zwane and Maritzburg United star Siphesihle Ndlovu due to fitness concerns, while on-form Orlando Pirates midfielder Xola Mlambo is notably absent, along with Keagan Dolly and injured France-based ace Bongani Zungu.
Bafana are second in Group E on goal difference behind Libya with four points from two games.
Nigeria are third with three points, while Seychelles have yet to open their account, having scored once and conceded eight times.
Bafana started their continental qualifying campaign with a memorable 2-0 win over Nigeria in Uyo on June 10 last year.
Goalkeepers: Itumeleng Khune (Chiefs), Ronwen Williams (SS Utd), Darren Keet (Wits).
Defenders: Ramahlwe Mphahlele (Chiefs), Motjeka Madisha, Thapelo Morena (Downs), Siyanda Xulu (Maritzburg), Thulani Hlatshwayo, Buhle Mkwanazi, Sifiso Hlanti (Wits), Innocent Maela (Pirates).
Midfielders: Dean Furman, Teboho Mokoena (SS Utd), Lebogang Maboe, Hlompho Kekana, Sibusiso Vilakazi (Downs), Thabo Nodada (CT City), Kamohelo Mokotjo (Brentford), Vincent Pule (Pirates).
Strikers: Lebogang Phiri (Guingamp, France), Dino Ndlovu (Hangzhou, China), Percy Tau (Royal Union, Belgium), Lebo Mothiba (Racing Strasbourg, France), Phakamani Mahlambi (Downs).