The public humiliation of Mourinho stipping the 2018 World Cup winner of his vice-captaincy role has seen their relationship reach a new low.
However, the news will no doubt set the likes of FC Barcelona and Juventus on high alert, having reportedly targeted the France international during the off-season.
United's executive vice-chairman reportedly valued Pogba at a staggering world-record £200m and has previously shown his unwillingness to negotiate cut-price deals in the case of Anthony Martial earlier this year.
According to The Mirror, Mourinho's recent spat with the eccentric midfielder has led him to request his transfer in the January transfer window.
With suggestions that the ongoing debacle has caused fractions in the dressing room, the club's hierarchy will need to assess whether they let go of the club-record signing - or the manager they've publically backed several times this year.