The defeat was Mourinho's heaviest at home in his career, and he has now lost two of his first three league games for the first time.
As a result, the tension with the media escalated and emotions clearly ran high as the former Chelsea boss claimed he's more successful than any other current manager in the Premier League.
"I won more Premierships alone than the other 19 managers together," Mourinho said, as quoted by the BBC. "Three for me and two for them.
"Respect, respect, respect man."
With United's lacklustre displays in recent times coming under scrutiny, the Red Devils notably played with more vigour and purpose which the Portuguese tactician eluded to.
"To play offensively or for a certain result? Today we were aggressive, we press high.
"Tottenham couldn't make two passes coming from the back. They made lots of mistakes because of our pressure high.
"In the first half, zero corners, zero lateral free-kicks, zero frontal free-kicks. On minute 50 they have one corner and score a goal and with that goal you want to transform the story of the game.
"But don't lose your time. Today I had proof that the best judge in football are the supporters. They are the best judge."
It was a passionate news conference last night ???? pic.twitter.com/6WnmuiUdU5— BBC Sport (@BBCSport) August 28, 2018