Manchester City 4-0 Fulham
Holders Manchester City had easy passage to the fifth round after thumping ten-man Fulham 4-0 at the Etihad Stadium.
The Championship side had a horrible start after their captain Tim Ream was sent off in just the sixth minute of the match, conceding a penalty in the process that was converted by IIkay Gundogan.
Bernardo Silva made doubled in the 19th minute before Jesus netted a late double to take the Citizens out of sight.
Pep Guardiola's troops will be back to another cup action when they host rivals Manchester United in the League Cup semi-final second-leg on Wednesday night.
Shrewsbury Town 2-2 Liverpool
Liverpool let slip a two goal lead in their fourth-round tie against League One side Shrewsbury Town at Montgomery Waters Meadow.
Curtis Jones gave the Reds the lead in the 15th minute while an own goal by Donald Love barely a minute into the second stanza gave Liverpool a two-goal cushion.
Shrewsbury worked their way back to the game as second-half substitute Jason Cummings pulled a goal back in the 65th minute from the penalty before he levelled matters with 15 minutes left to complete his brace and earn his side a replay at Anfield.
Tranmere Rovers 0-6 Manchester United
Manchester United cruised to the fifth round after crushing third-tier side Tranmere Rovers 6-0 at Prenton Park.
Harry Maguire, Diogo Dalot, Jesse Lingard, Phil Jones and Anthony Martial gave United a whopping 5-0 lead in the first half, while Mason Greenwood completed the rout with a penalty 11 minutes after the halftime break.
Ole Gunnar Solskjaer's troops will be League Cup action on Wednesday night away at rivals Manchester City, as they look to overturn a 3-1 deficit.