The Gunners left Anfield with their tails between their legs in the reverse fixture at the start of the season as the Reds ran rampant with goals from Roberto Firmino, Sadio Mane, Mohamed Salah and Daniel Sturridge earning a 4-0 whitewash.
Wenger’s men now enter this weekend’s Premier League clash trailing their rivals by one point in the standings, meaning a win would catapult the north London giants into the top four, and Wenger hopes they can do just that on home soil.
"When you have such a long career as I have, you have some defeats unfortunately that hurt you for the rest of your life," said Wenger, whose side enter the clash on the back of their 1-0 Carabao Cup quarter-final win over West Ham on Tuesday.
"I believe what is interesting in football is you always have a time to make up for it. When you can put things right, do it.
"So let's focus on what is in front of us and turn up on Friday night with a completely different performance.
"The motivation is there. This squad has a good mentality and it is about us, to make sure we are on top of our game. We must play with pace and a determined attitude."