But just who they will face remains to be seen after Zambian champions Zanaco could manage just a 3-2 win over Mbabane Swallows with the return leg in Swaziland to come. Those two away goals could prove crucial as Zanaco led 2-0 and 3-1 in the game but could not close the fixture out.
Egyptian giants Zamalek thumped Gazelle from Chad 7-0 in the home leg of their tie to record their record win in African club competition, beating a 6-0 thrashing of APR in 2002.
Ghana’s Asante Kotoko beat Equatorial Guinea side Sony de Ela Nguema by the same scoreline, also a record for them in the competition since it has been the Champions League.
Nigerian side Kano Pillars defeated Central African Republic’s Olympique Real 5-1, while Kenyan champions Tusker dispatched St Michel United of the Seychelles 4-1.
Cote d’Ivoire side AFAD recorded a 5-1 victory over Sierra Leone’s Diamond Stars, with all five goals scored by Mamadou Soro in what was a superb individual performance. He had only netted two goals in 13 League appearances this season before this game.
Cameroon’s Union Douala will have their work cut-out in the second leg of their tie against the Liberia Ship Corporate Registry after they could only manage a 2-1 home win on Sunday.
Algeria's JSM Béjaïa have the upperhand in their tie with Niger's Olympic Niamey after a 3-0 home win in the first leg, while FUS Rabat from Morocco edged Gambia's Real de Banjul 1-0 in their home leg.
Botswana’s Mochadi Centre Chiefs managed a 1-0 away win at Mozambique side Maxaquene that puts them in the driving seat in that tie. Former Santos and Vasco da Gama striker Jerome Ramatlhakwane scored for them.
Cameroon’s CotonSport were surprisingly held 0-0 by Uganda Revenue Authority in their fortress of Garoua that leaves that tie on a knife edge.
Finally, Nigeria’s Enugu Rangers received a walkover 3-0 victory after Sporting Príncipe from Sao Tome e Principe failed to show up for their game.
Preliminary round, first leg, results:
APR FC (Rwanda) 1-2 Vital'O (Burundi)
Bizertin (Tunisia) 1-1 Alittihad (Libya)
JSM Bejaia (Algeria) 3-0 Olympic FC (Niger)
Fath Union Sport de Rabat (Morocco) 1-0 Real Banjul (Gambia)
Orlando Pirates (South Africa) 5-0 Djabal FC (Comoros)
Moghreb Tetouan (Morocco) 1-0 Casa Sport (Senegal)
Primeiro de Agosto (Angola) 4-2 AS Adema (Madagascar)
St. Michel United (Seychelles) 1-4 Tusker (Kenya)
Zanaco (Zambia) 3-2 Mbabane Swallows (Swaziland)
Kano Pillars (Nigeria) 5-1 Olympique Bangui (Central Africa)
Jamhuri (Zanzibar) 0-3 Saint George (Ethiopia)
CotonSport (Cameroon) 0-0 URA (Uganda)
Simba SC (Tanzania) 0-1 Clube Recreativo Libolo (Angola)
Dynamos (Zimbabwe) 3-0 L.S.C Lesotho (Lesotho)
Maxaquene (Mozambique) 0-1 Mochudi C.Chiefs (Botswana)
Rangers (Nigeria) 3-0 Sporting Principe (Angola)
AS Vita Club (Congo) 3-0 Dynamic (Togo)
AC Leopards (Cong) 2-0 CF Mounana (Gabon)
Asante Kotoko (Ghana) 7-0 Sony de Ela Nguema (Equatorial Guinea)
ASPAC FC (Benin) 1-1 ASFY (Burkina Faso)
Union Douala (Cameroon) 2-1 LISCR (Liberia)
AFAD (Ivory Coast) 5-1 Diamond Stars (Sierra Leone)
Horoya (Guinea) 0-0 Sewe Sport (Ivory Coast)
Zamalek (Egypt) 7-0 Gazelle FC (Chad)