The Chelsea star, who has been key to most of Nigeria's best attacking plays at the 2013 CAF African Nations Cup, picked up two yellow cards during the group stages.
"I found out last night and I am so so upset about it," he told KickOffNigeria.com exclusively on Thursday morning. "I was really looking forward to helping the team get past this game."
Mikel joins fellow midfielder Fegor Ogude, who also accumulated two yellow cards during the group stages.
But Mikel remains confident the team can do the job against the tournament favourites
"I'm very disappointed to miss the game. But I am confident that the lads can do the job without us.
"We have a good team here and the new players are working very hard. I have tried to take some responsibility and speak to them, motivate them and give them advice.
"I am sure they will do the country proud."