Patosi was left out of the Bafana Bafana squad for the 2013 Africa Cup of Nations due to fitness concerns, but on a night when the national team battled to score against Cape Verde, he netted again for Lokeren.
The 20-year-old was introduced midway through the second half with the score at 2-2 and inspired his team to four more goals.
There was also a return for Daylon Claasen after six months on the sidelines through injury as Lierse were held 0-0 by Waasland-Beveren.
Claasen is another who missed out on the Nations Cup through injury, but now has the second half of the season to prove that his fitness and win a move to a bigger European league, something that seemed inevitable before he injured his knee last July.
Darren Keet was in goal for Kortrijk as they won 4-0 at home to Germinal Beerschot, a much-needed victory as they seek a place in the top-six this season.
Finally, David Somma was on the bench for English Championship side Leeds United in their 1-0 win over bottom side Bristol City, while former Bafana skipper Steven Pienaar is in action tonight as his Everton side travel to Southampton.