The Frenchman is frustrated at what was termed “poor tournament management”, with the issue of win bonuses apparently central to the disruptions within the camp.
LeRoy handed a letter of resignation to the DR Congo football association on Thursday night, with his assistant, Sebastian Migne, also leaving his post.
It is unclear whether the move is an attempt to force the hand of the association, but it has left the country’s preparations in tatters.
LeRoy is one of the most experienced coaches in African football and would have been appearing in his seventh Nations Cup finals.
With the top two men in the technical team gone, it is unclear now who is leading the side in training leading up to the Ghana clash.
DR Congo are in Group D along with the Black Stars, Mali and Niger and are based in Port Elizabeth.