Chiefs played to a second successive draw on the weekend when they were held 1-1 at home by University of Pretoria.
However, the Soweto giants still boast an excellent home record, with six wins and two draws from eight matches.
Amakhosi are placed first on the standings with 32 points from 15 matches.
AmaZulu shared the spoils in a match for the third successive time when they played to a 1-1 draw away to Chippa United on the weekend.
The Durban side has recorded four wins and four losses from their eight away matches so far this season. Usuthu are placed 16th on the Premiership log with 12 points from 15 matches.
In head-to-head stats, Chiefs and AmaZulu have met in 47 League matches since 1985.
Amakhosi have traditionally dominated the fixture, claiming 28 wins compared to just seven for Usuthu.
Chiefs’ home record against the Durban side is even more one-sided: 17 wins from 24 matches and just two defeats.
When the teams met earlier this season the Soweto side ran riot in a home fixture for Usuthu, racking up a massive 6-0 victory with Bernard Parker scoring four goals.
kick-off at 19h30.