Kick-off at 19h30.
Leopards defeated University of Pretoria 2-1 in their last outing, their third League win this season.
The Limpopo side will be looking to improve on a home record which has seen them win just one of six matches so far this season.
Lidoda Duvha are placed ninth on the log with 15 points from 12 matches.
AmaZulu suffered their seventh defeat of the season in their last outing, going down 1-0 at home to Free State Stars.
The Durban side has recorded just two points from a possible 18 on their travels so far this season.
Usuthu are placed 16th on the log with nine points from 12 matches.
In head-to-head stats, Leopards and AmaZulu have met in 10 League matches since 2001/02. Each side has five wins to their name, while Usuthu has scored 16 goals to Leopards' 13.
Leopards has recorded three victories and two defeats in their five home matches against the Durban visitors.
Last season Lidoda Duvha won 1-0 in Durban, while Usuthu claimed a 4-1 victory in the return game in Polokwane.
Leopards' line-up from their 2-1 win over Tuks: Maphaha (Mtshali 49'), Dzaga, Sithole, Khoza, Xakane, Bobe (Madbusela 86'), Nkambule, Munganga, Maake, Ramagalela, Amidu (Monama 46').
AmaZulu's line-up from their 1-0 loss to Stars: Zikalala, Teyise, Van Heerden, Nyadombo, P. Cele, Zhuwawo, Kgatla, Zwane (Mshengu 90 + 1'), Mokoro (Mbele 90 +1'), Khumalo (Lekata 68'), A. Dlamini.