The Urban Warriors have not beaten Chiefs away from home in the past two seasons and now face a wounded Amakhosi, who lost their first League game against Platinum Stars in their last match.
"The history is the past but if you look back, playing Chiefs in the last five games ... we haven't gained too much out there," Ajax coach Jan Pruijn says. "Now it's a new game and playing in Polokwane will be much better then playing at FNB Stadium because of the pitch, this will help with our passing game.
"We are going to play the log leaders and there is so much that can be said about Chiefs – they only got their first loss against Platinum Stars."
Chiefs went 11 matches without a loss this season, but Pruijn reckons that run would have ended this week, against either Ajax or Orlando Pirates this weekend.
"I knew that the end of Chiefs' unbeaten run would come closer and closer; if it wasn't last week it was going to be on Tuesday, if not then it was going to be against Pirates," he says.
"However, that's history, and in a way I think that we need to be very good and very prepared."
Pruijn says he is very aware of Ajax's poor record away from home, adding that he has a plan to beat Chiefs.
"There is always been talk that Ajax away have struggled but to me that doesn't matter, if you play at home or away it's going to be the same preparation.
"Unfortunately the results haven't come our way playing away so I can only say with four games left and playing Chiefs away I have a certain plan to win the game ..."
Striker Bradley Grobler is back from injury, while Nazeer Allie and Nhlanhla Shabalala will have to undergo late fitness tests. Koen van de Laak is still out with a calf injury but is expected to be back for the Maritzburg United match on Friday.