Hardly hours after he had called on Manqele to replace Siyabonga Nomvete, the Mamelodi Sundowns striker pulled a hamstring in a Premiership match against Maritzburg United on Sunday afternoon, forcing the Bafana coach into yet another change.
Igesund has also called up SuperSport United's George Maluleka to replace Steven Pienaar of Everton, who was also injured this weekend.
"I have called up Benni McCarthy to replace Manqele who in turn had replaced Nomvete," Igesund says.
Nomvete was carried off the pitch injured on Saturday evening during Moroka Swallows' match against Orlando Pirates.
Despite a fraught history with the national team, Benni McCarthy said in March that he would welcome a return to the Bafana fold.
Bafana Bafana leave for Sao Paolo on Monday morning to play five-time World Cup champions Brazil on Friday, September 7.