Kick-off for the match is 3pm.
Swallows finished second on the League standings last season, narrowly missing out on a first championship since 1965.
The Birds have been fairly quiet on the transfer front, retaining most of the squad that did duty last term. Winger Felix Obada is their only notable addition.
However, the Soweto giants have suffered one major loss in the departure of coach Gordon Igesund, who has taken up the reins with Bafana Bafana.
AmaZulu finished seventh on the log last term, just the second time in the PSL era (1996/97 onwards) that they have qualified for the Top 8 Cup.
Usuthu have also been relatively quiet on the transfer front. Prince Hlela and Sifiso Vilakazi are notable additions, but the loss of star midfielder Thamsanqa Sangweni to Mamelodi Sundowns is their main concern.
Swallows are playing in the MTN8 for the first time since losing the 2010 Final on penalties to Orlando Pirates. The Birds have won the competition twice (1975 and 1979) from seven appearances in the final.
AmaZulu are playing in the MTN8 for the first time since losing 4-1 on aggregate to 2009 champions Golden Arrows in the semi-finals. The Durban club appeared in the Top 8 Cup final once (1976) but lost to Kaizer Chiefs 8-2 on aggregate.
This MTN8 quarter-final will be the ninth cup meeting of Swallows and AmaZulu. Usuthu have certainly had the better of the encounters down the years, claiming four outright wins and two penalty shoot-out victories, compared to just two wins for the Birds, the last of which was way back in 1993.
The Durban side has eliminated their Soweto counterparts the last five consecutive times that the teams have met in cups, the most recent of which was a 2010 Nedbank Cup match that ended 2-2 before AmaZulu triumphed on penalties.
Across all competitions Swallows have a better head-to-head record, with 20 wins compared to AmaZulu's 15 from 54 matches.
The Birds will have home advantage for this MTN8 tie, but they have not beaten Usuthu in any of the last five League and cup matches in which they have played host to the team in green.
The teams' last meeting was a League match in March at Dobsonville Stadium, which Swallows won 1-1 with goals from Siyabonga Nomvete and Goodman Dlamini.