While Chiefs are likely to be without key players such as Siphiwe Tshabalala, George Lebese, Jimmy Jambo and Jimmy Tau owing to injury, Neeskens will also be forced to make some changes to his line-up as some of his players are either unfit or ineligible to play on Sunday.
"Clayton Daniels will miss the match [MTN8 on Sunday] as he is still serving suspension after picking up a red card in the Nedbank Cup final against SuperSport United late last year," says Sundowns on their official website.
"Alje Schut, who was brought in from Holland is also not available for the match as he picked up an injury during preseason. This means that Sundowns will be thin at centre back, as Wayne Arendse, signed from Santos, is still blending in.
"Other players who could miss the match are Siyabonga Ngubane, who picked up an injury at the Mopani Cup and Katlego Mphela, who is still out due to an operation he underwent during the break.
Siyanda Xulu might also not be considered for the clash as he has just only returned from Russia, where he was undergoing trials.
Sundowns and Chiefs have played each other 79 times in all competitions since 1985, with the Soweto-based side winning 34 matches while the Brazilians have managed 21 victories.
Sunday's clash will be the 26th Cup meeting between the two giants since 1985.
Chiefs have a better Cup record against the Brazilians with 12 wins and just four losses.