The big game is the Cape Town Derby between Santos and Vasco Da Gama.
While other relegated side Jomo Cosmos' first game is away to African Warriors.
The Vodacom League promoted sides Roses United will host Witbank Spurs while Milano United will face Blackburn Rovers in the Eastern Cape.
The League season kicks-off on the second week of August 2012.
First Division fixtures:
MP Black Aces vs. Sivutsa Stars
African Warriors vs. Jomo Cosmos
FC AK vs. Carara Kicks
Santos vs. Vasco Da Gama
FC Cape Town vs. Thanda Royal Zulu
Blackburn Rovers vs. Milano United
Roses United vs. Witbank Spurs
Bay United vs. United FC