21 players make up the travelling squad, with Russia-based Nompumelelo Nyandeni joining her compatriots the next day in Germany.
Banyana will play two friendly internationals, against Cameroon and Olympic hosts Great Britain during their time abroad.
South Africa face Cameroon in Lille, France on Wednesday, July 11. Kick-off is at 2pm.
Cameroon will be the only other African country representing the continent at the Olympics.
They have been drawn in Group E along with Great Britain, New Zealand, and Brazil.
South Africa has been drawn in Group F along with Japan, Canada and Sweden.
The second fixture will take place in Birmingham, England against Great Britain on Sunday, July 15, kick-off is at 2.30pm (4.30pm SA time).
The squad is expected back in the country on Tuesday, July 17.
With several players coming from the Sasol League Championships in Durban this past week, Joseph Mkhonza is hopeful the team will carry the same energy and momentum to Europe.
Six Banyana Banyana players played in the championships – Zamandosi Cele (Durban Ladies); Leandra Smeda and Nocawe Skiti (Cape Town Ladies); Nothando Vilakazi and Portia Modise (Palace Super Falcons) and Sanah Mollo (Bloemfontein Celtic).
"The players that took part in the championship will be given time off to recover to avoid overworking them as we approach this very important phase of preparations," Mkhonza says.
"Most of the girls that went there took part, and I was very happy with their enthusiasm at the tournament. Defender Janine van Wyk's rehabilitation is nearing conclusion and we hope she will be ready for our matches in Europe."
Mkhonza adds that with the time left to prepare for the Olympics, he would like to fine-tune his squad and use the experience gained during the African Women’s Cup qualifiers to get the team ready for London.
"This is the last chance to work on any of our shortcomings. We have to finalise our strategy for the Olympics and build on what we've been working on since our qualification.
"The matches will help us gauge how far we have come and give us a state of our readiness. This is also the opportunity to make sure the players understand the importance of competing on the Olympic stage," Mkhonza says.
Banyana Banyana are already in camp ahead of their departure and will be training at the Wits Education campus in Johannesburg.
The Banyana Banyana squad travelling to Germany and England:
Thokozile Mndaweni (University of Johannesburg)
Roxanne Barker (Pepperdine University, USA)
Andile Dlamini (Sundowns Ladies)
Refiloe Jane (Sundowns Ladies)
Lebogang Mabatle (Hallelujah Zebra Force)
Nothando Vilakazi (Palace Super Falcons)
Amanda Sister (Liverpool Ladies)
Janine van Wyk (Palace Super Falcons)
Zamandosi Cele (Durban Ladies)
Leandra Smeda (Cape Town Roses)
Nocawe Skiti (Cape Town Roses)
Kylie-Ann Louw (Stephen F Austin, USA)
Amanda Dlamini (University of Johannesburg)
Mary Ntsweng (TUT Ladies)
Noko Matlou (University of Johannesburg)
Portia Modise (Palace Super Falcons)
Gabisile Hlumbane (Kovsies Ladies)
Sanah Mollo (Bloemfontien Celtic)
Robyn Moodaly (High Performance Centre)
Nompumelelo Nyandeni (FC Rossiyanka, Russia)
Andisiwe Mgcoyi (Sundowns Ladies)
Jermaine Seoposenwe (Santos)