Mbuyane was forced to leave the pitch in the first half of the Nedbank Cup match against Ethekwini Coastal on Saturday because of what was suspected to be a calf injury.
But 'Juju' assures The Ghost that he will be available for the Soweto Derby against Kaizer Chiefs this Saturday.
"It's not a serious injury; I can walk now," he tells KickOff.com. "I am going to see the physio on Monday but I am confident I will be up and running by Tuesday.
Meanwhile, Pirates will miss Andile Jali for the League game against Santos in Cape Town on Wednesday as he is suspended.
Jali received his third booking during the Nedbank Cup game on Saturday.