The Three Lions will be going all out as a number of their players are keen to impress coach Fabio Capello as he looks to name his 23-man squad.
The former Real Madrid boss has a number of selection dilemmas for his side's first warm-up match before they head to South Africa, most notably in goal.
David James has been given extra time to recover from last week's FA Cup Final, so Robert Green and Joe Hart are likely to play 45 minutes each, while defence remains an issue for Capello too.
Jamie Carragher has been brought out of international retirement to be named in the 30-man provisional squad, and Ledley King has also been recalled to the squad despite not playing for his country since 2007.
The duo will be looking to impress Capello in the two warm-up matches before the World Cup, as will captain Rio Ferdinand and Glen Johnson, who have both had injury-hit seasons.
The Chelsea quartet of John Terry, Ashley Cole, Frank Lampard and Joe Cole will all miss the friendly with Mexico after featuring in the FA Cup Final and that could mean Capello is set to experiment with a new formation.
There have been reports the Italian could ditch his 4-4-2 formation in favour of a 4-4-1-1 formation in an attempt to get the best out of Steven Gerrard playing just behind Wayne Rooney in attack.
Results leading up to the World Cup have been impressive for England, with nine wins out of ten qualifying matches, including 4-1 and 5-1 wins over Croatia and a 3-1 victory against Egypt in their last match.
The former Atletico Madrid manager Javier Aguirre has guided Mexico to three successive wins in the past couple of weeks. After a goalless draw with Ecuador, Alberto Medina scored the only goal of the game against Senegal in Chicago before Andres Guardado netted in a 1-0 win over Angola to round off their three-match tour of America with a victory.
Medina then scored again in a 1-0 win over Chile last week which means they have gone five matches without conceding.
The main man for England will undoubtedly be Wayne Rooney.
The Manchester United striker has netted 34 times in 44 games for his club this season and not only has he been the Red Devils' best player, but he was England's top scorer in qualifying, finishing second in the European qualifying goal scoring charts with nine goals.