'Chicharito' (Little Pea) has eight goals already for Guadalajara, who set a Mexican league record for the most consecutive victories to start the season, winning a sixth game with a 1-0 victory over Pachuca last weekend.
Other stars called up by Mexican national team Coach Javier Aguirre include veteran Blanco, Gerardo Torrado and Jonny Magallon.
The game in San Francisco kicks off Mexico's six-city US tour that will also visit Los Angeles, Charlotte, New York, Chicago and Houston ending on May 13.
Bafana Bafana and Mexico open the World Cup at Soccer City on June 11.
The Mexican squad:
Goalkeepers: Luis Ernesto Michel (Guadalajara/MEX), Jonathan Orozco (Monterrey/MEX)
Defenders: Paul Aguilar (Pachuca/MEX), Efrain Juarez (UNAM/MEX), Hugo Ayala (Atlas/MEX), Jonny Magallon (Guadalajara/MEX), Jorge Torres Nilo (Atlas/MEX), Adrian Aldrete (Morelia/MEX)
Midfielders: Gerardo Torrado (Cruz Azul/MEX), Israel Castro (UNAM/ MEX), Luis Miguel Noriega (Puebla/MEX) Braulio Luna (San Luis/MEX)
Forwards: Aldo Jesus De Nigris (Monterrey/MEX), Javier Hernandez (Guadalajara/MEX), Pablo Barrera (UNAM/MEX), Enrique Esqueda (Club America/ MEX), Angel Eduardo Reyna (Club America/MEX), Cuauhtemoc Blanco (Veracruz/MEX)