Bernard Parker and Siphiwe Tshabalala scored a goal in each half for Amakhosi, while former Chiefs man Brian Amidu scored a consolation goal for Leopards in the final minute.
Chiefs dominated from the outset, and only for small period in the first half were they ever in danger of conceding. The visitors were a little lucky to escape with the concession of just two goals.
In the fourth minute, Siphiwe Tshabalala supplied a pin-point corner-kick to find the towering Tefu Mashamaite, but the defender's header bounced off the crossbar.
Eight minutes later George Lebese was pulled down in the box by Ernot Dzaga and the referee pointed to the penalty spot.
Parker stepped up and made no mistake, scoring his fifth goal of the season.
Chiefs seemed to relax a bit after going in front and Leopards managed to create a couple of chances of their own.
In the 20th minute some sloppy defending allowed Raymond Monama a free shot on the edge of the box but he fired inches wide.
In the 36th minute it took the heroics of Siboniso Gaxa to keep his side in the lead as he slid in front of a Rodney Ramagalela cross – had he missed, Thabo Mongalo would surely have tapped home from close range.
After that Chiefs took control of the game yet again and were dictating terms going into the break.
Chiefs created chance after chance in the second half, the first coming after some swift passing on the edge of the box, which resulted in Parker pulling a shot wide.
Eight minutes later Parker was in the thick of the action again, this time dribbling his way past the last defender on the edge of the box, but he failed to beat the keeper one-on-one.
Finally, in the 70th minute, Chiefs were able to find their second goal.
Tshabalala picked up ball on the edge of the box, dribbled past two players and then calmly passed the ball into the back of net.
Leopards tried to find their way back into the game and they created a nervous few minutes for Chiefs, and Amidu scored a minute from time. But it was too little too late for Lidoda Duvha as Chiefs walked away victorious.