The tournament makes a return this year after a hiatus in 2012, with Botswana and Swaziland contesting the opening tie (kick-off: 12h30).
Botswana hosted the last competition, finishing third. Swaziland have not won a match at the event since 2004, a record they will be desperate to improve on.
East African guest nation Kenya will take on Mauritius in the second game of the day at 15h00, a match that comes out of Group A.
There will be an opening ceremony at the Setsoto Stadium, starting at 18h00, before the hosts Lesotho entertain the Comoros (KO: 20h00).
South Africa will open their account against Seychelles on Wednesday at the Mafeteng Stadium, with Zambia and Namibia completing Group C.
The top team in each pool will advance to the semi-finals on December 12, with the third-place play-off and final taking place two days later.
A: Lesotho, Comores, Mauritius, Kenya.
B: Angola, Madagascar, Mozambique.
C: South Africa, Seychelles, Namibia, Zambia.
D: Botswana, Swaziland, Zimbabwe.